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Workshop se koná 24 -25. 10. 2011 v konferenčním centru AVČR Zámek Liblice
Dear colleagues,
Neurodegenerative diseases such as Alzheimer, Parkinson and Huntington disease are caused or accompanied by a major loss of neurons. A slow progression of the diseases allows treat symptoms with new pharmaceuticals, to develop cell transplantation therapies and to invent molecular genetic approaches. Before all new promising therapies will be accessible for patients, appropriate animal models are critical for understanding the fundamental mechanisms causing the diseases and for development of safety and efficient therapeutic approaches. In this respect large animal models, with a close physiology to human brain, are extremely important.
To offer a platform for the efficient exchange of research experience and creation of new ideas for therapy of neurodegenerative diseases, we organize:
Workshop
„Large Animal Models of Neurodegenerative Diseases“
From 24th -25th October 2011
To be held in the Conference Centre of the Academy of Sciences of the Czech Republic-Chateau Liblice
Liblice 61, 277 32, Byšice, Czech Republic
Organized by:
Institute of Animal Physiology and Genetics AS CR, v. v. i., Czech Republic; Institute of Anatomy, Aarhus University, Denmark; Department of Neurology, University of Muenster, Germany; Institute of Neurobiology, Kosice, Slovak Republic
Registration is opened
http://www.chateau-liblice.com/large-animal-models-of-nd.html
(See Poster, please)
Send a title of your poster presentation to:
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Scientific Program
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WORKSHOP:
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Large Animal Models of Neurodegenerative Diseases
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LOCATION:
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Liblice Chateau, Czech Republic
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DATES:
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October 23-25, 2011
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Sunday, October 23
1:00 pm – 10:00 pm Arrival and Check-in
Monday, October 24
9:00 am – 9:15 am Welcome / Introductory Comments by Organizers
9:15 am – 9.45 am Key Note Speaker
David Howland (CHDI Foundation, Princeton, USA)
“Role of Animal Models in Neurodegenerative Diseases”
9:45 am- 10:45 am Alzheimer Disease
The first part
10:15 am – 11:15 am Coffee Break
11:15 am – 12: 45 am Alzheimer Disease
The second part
1:00 pm – 2:00 pm Lunch
2:00 pm – 4:00 pm Huntington Disease
The first part
4:00 pm - 4:20 pm Zinc finger nucleases (ZFNs) for transgenesis
4:20 pm – 4:50 pm Coffee Break
4:50 pm – 6:30 pm Poster Session
Send a title of your poster presentation to:
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7:30 pm- 11.00 pm Dinner
Tuesday, October 25
8:30 am – 10:30 am Huntington Disease
The second part
10:30 am – 11:00 am Coffee Break
11:00 am – 1:00 pm Parkinson Disease
The first part
1:00 pm– 2:00 pm Lunch
2: 00 pm – 5:00 pm Parkinson Disease
The second part
5:00 pm – 5:30 pm Coffee Break
5:30 pm – 6:00 pm Closing discussion
The Proposed Speakers:
ALZHEIMER DISEASE
Eckhardt and Eva-Maria Mandelkow
On relationship between Abeta expression and taupathology
Heiko Braak
On early changes in young persons
David Mann
Will be specified
Peter St. George Hyslop
On animal models in general
Ida Holm
Characterization of the APPsw pig model of Alzheimer disease
Jannik Jakobsen
Development of the 'master-pig' with both APPsw and PS1 mutations.
Michal Novak
“Concluding discussion of Alzheimer disease part”
PARKINSON DISEASE
Jens Christian Sørensen
Parkinson disease and stem cell transplantation evaluated in a porcine model
Mette Slot Nielsen
A Porcine model of MPTP induced Parkinsonism
Carsten R Bjarkam
Neurosurgical techniques for high precision intracerebral implantation of neuromodulatory devices, stem cells and viral vectors
Knud Larsen
Identification of Parkinson genes and development of Parkinson models in pigs
Speaker one from the Boston group
Monkey models of Parkinson disease and neural transplantation
Speaker one from the London (Tipu Aziz group)
Monkey models of Parkinson disease and deep brain stimulation
Speaker one from the New York (M Kaplitt group)
Monkey models of Parkinson disease and gene therapy
Carsten R Bjarkam
“Concluding discussion of Huntington disease part”
HUNTINGTON DISEASE
Neil Aronin
“Testing safety and efficacy of gene silencing in sheep”
Marian Di Figlia
“The large animal models of HD in the perspective of recent advances on HD140Q/140Q mouse model”
Jenny Morton
“Behavioral testing in HD transgenic sheep”
Anthony W.S. Chan
“Modeling Huntington’s disease in nonhuman primates”
Martin Marsala
Marta Valenza, Chiara Zuccato
Marian Hruska-Plochan
“Minipig model of Huntington disease: F0, F1 and F2 generations, their importance and potential”
Marian Di Figlia
“Concluding discussion of Huntington disease part |
